Article

Cell – ECM interactions play distinct and essential roles at multiple stages during the development of the aortic arch

2020-04-08

Abstract excerpt

<h4>Rationale</h4> Defects in the morphogenesis of the 4 th pharyngeal arch arteries (PAAs) give rise to lethal birth defects. Understanding genes and mechanisms regulating PAA formation will provide important insights into the etiology and treatments for congenital heart disease. <h4>Objective</h4> Cell-ECM interactions play essential roles in the morphogenesis of PAAs and their derivatives, the aortic arch a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 49c0aa4c-1704-55ff-9731-4692641c99e3
DOI: 10.1101/2020.04.07.029926

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell – ECM interactions play distinct and essential roles at multiple stages during the development of the aortic archDOI 10.1101/2020.04.07.029926Read

Identification of novel buffering mechanisms in aortic arch artery development and congenital heart diseaseSemantic proximity Read

Development of the human aortic arch system captured in an interactive three‐dimensional reference modelSemantic proximity Read

Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner.Semantic proximity Read

<i>Tbx1</i>expression in pharyngeal epithelia is necessary for pharyngeal arch artery developmentSemantic proximity Read

Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart DiseaseSemantic proximity Read

<i>Pax9</i> is required for cardiovascular development and interacts with <i>Tbx1</i> in the pharyngeal endoderm to control 4 <sup>th</sup> pharyngeal arch artery morphogenesisSemantic proximity Read

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending AortopathiesSemantic proximity Read

A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivativesSemantic proximity Read

Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesisSemantic proximity Read

Developmental Mechanisms of Aortic Valve Malformation and DiseaseSemantic proximity Read

Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis.Semantic proximity Read

CXCL12-CXCR4 signalling plays an essential role in proper patterning of aortic arch and pulmonary arteries.Semantic proximity Read