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Article

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington's disease models.

Journal of molecular medicine (Berlin, Germany) - 1 Feb 2016

Smalley Joshua L, Breda Carlo, Mason Robert P, Kooner Gurdeep, Luthi-Carter Ruth, Gant Timothy W, Giorgini Flaviano

Abstract excerpt

UNLABELLED: Huntington's disease (HD) is a genetic disease caused by a CAG trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin (HTT) protein, ultimately leading to neuronal loss and consequent cognitive decline and death. As no treatments for HD currently exist, several chemical screens have been performed using cell-based models of mutant HTT toxicity. These screens measured single...

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Identifiers

PMID: 26428929
DOI: 10.1007/s00109-015-1344-5
PMCID: PMC4762922

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HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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