Article

Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer’s disease

2024-12-13

Abstract excerpt

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by heterogeneous molecular changes across diverse cell types, posing significant challenges for treatment development. To address this, we introduced a cell-type-specific, multi-target drug discovery strategy grounded in human data and real-world evidence. This approach integrates single-cell transcriptomics, drug perturbation da...

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Literature Corpus work: 1f9909b7-c964-5c08-9496-1d0ef7863865
DOI: 10.1101/2024.12.09.627436

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