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Article

Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.

Kidney international - 1 Jun 2006

Peng J-B, Bell P D

Abstract excerpt

Gene mutations in WNK4 kinase cause a genetic form of hypertension by affecting multiple ion transport pathways through different mechanisms. Cai et al. report that the inhibitory effect of WNK4 on the thiazide-sensitive sodium-chloride cotransporter occurs through the lysosomal degradation pathway in mammalian cells.

Read the complete abstract on PubMed

Topics

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Share to Carrier Proteins
Share to Hypertension
Share to Ion Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Tubules, Distal

Share to Lysosomes

Share to Protein Serine-Threonine Kinases

Share to Pseudohypoaldosteronism

Share to Sodium Chloride Symporters

Source

Identifiers

PMID: 16761023
DOI: 10.1038/sj.ki.5000435

Genes

WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.PMID 16761023Read ↗

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WNK kinases regulate thiazide-sensitive Na-Cl cotransport.Semantic proximity Read ↗

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