Article
WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2014
Chávez-Canales María, Zhang Chong, Soukaseum Christelle, Moreno Erika, Pacheco-Alvarez Diana, Vidal-Petiot Emmanuelle, Castañeda-Bueno María, Vázquez Norma, Rojas-Vega Lorena, Meermeier Nicholas P, Rogers Shaunessy, Jeunemaitre Xavier, Yang Chao-Ling, Ellison David H, Gamba Gerardo, Hadchouel Juliette
Abstract excerpt
The with-no-lysine (K) kinases, WNK1 and WNK4, are key regulators of blood pressure. Their mutations lead to familial hyperkalemic hypertension (FHHt), associated with an activation of the Na-Cl cotransporter (NCC). Although it is clear that WNK4 mutants activate NCC via Ste20 proline-alanine-rich kinase, the mechanisms responsible for WNK1-related FHHt and alterations in NCC activity are not as clear. We tested...
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