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Article

Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease.

Neurobiology of aging - 1 Dec 2015

Oeda Tomoko, Umemura Atsushi, Mori Yuko, Tomita Satoshi, Kohsaka Masayuki, Park Kwiyoung, Inoue Kimiko, Fujimura Harutoshi, Hasegawa Hiroshi, Sugiyama Hiroshi, Sawada Hideyuki

Abstract excerpt

Homozygous mutations of the glucocerebrosidase gene (GBA) cause Gaucher disease (GD), and heterozygous mutations of GBA are a major risk factor for Parkinson's disease (PD). This study examined the impact of GBA mutations on the longitudinal clinical course of PD patients by retrospective cohort design. GBA-coding regions were fully sequenced in 215 PD patients and GD-associated GBA mutations were identified in...

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PMID: 26422360
DOI: 10.1016/j.neurobiolaging.2015.08.027

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