Article
Pre-s mutation is a significant risk factor for hepatocellular carcinoma development: a long-term retrospective cohort study.
Digestive diseases and sciences - 1 Mar 2013
Sinn Dong Hyun, Choi Moon Seok, Gwak Geum-Youn, Paik Yong-Han, Lee Joon Hyeok, Koh Kwang Cheol, Paik Seung Woon, Yoo Byung Chul
Abstract excerpt
BACKGROUND: Several cross-sectional studies have shown an association between pre-S mutation and hepatocellular carcinoma (HCC). AIMS: We aim to verify whether pre-S mutation represents a risk for HCC development in a longitudinal way. METHODS: A total of 195 patients with chronic HBV infection [...
Topics
- Adult
- Carcinoma, Hepatocellular
- Cohort Studies
- Female
- Gene Expression Regulation, Viral
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Incidence
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Protein Precursors
- Retrospective Studies
- Risk Factors