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Article

Molecular Requirements for Transformation of Fallopian Tube Epithelial Cells into Serous Carcinoma

1 Oct 2011

Abstract excerpt

Although controversial, recent studies suggest that serous ovarian carcinomas may arise from fallopian tube fimbria rather than ovarian surface epithelium. We developed an in vitro model for serous carcinogenesis in which primary human fallopian tube epithelial cells (FTECs) were exposed to potentially oncogenic molecular alterations delivered by retroviral vectors. To more closely mirror in vivo conditions,...

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Share to Ovarian cancer diagnosis and treatment
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PMID: 22028616
DOI: 10.1593/neo.11138

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