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Article

AgRP Neurons Regulate Bone Mass.

Cell reports - 6 Oct 2015

Kim Jae Geun, Sun Ben-Hua, Dietrich Marcelo O, Koch Marco, Yao Gang-Qing, Diano Sabrina, Insogna Karl, Horvath Tamas L

Abstract excerpt

The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2 gene deletion, in which AgRP neuronal function was impaired, were osteopenic. This phenotype was rescued by cell-selective reactivation of Ucp2 in AgRP neurons....

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Identifiers

PMID: 26411686
DOI: 10.1016/j.celrep.2015.08.070
PMCID: PMC5868421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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