Article
Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses.
Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013
Matarese Giuseppe, Procaccini Claudio, Menale Ciro, Kim Jae Geun, Kim Jung Dae, Diano Sabrina, Diano Nadia, De Rosa Veronica, Dietrich Marcelo O, Horvath Tamas L
Abstract excerpt
Whole-body energy metabolism is regulated by the hypothalamus and has an impact on diverse tissue functions. Here we show that selective knockdown of Sirtuin 1 Sirt1 in hypothalamic Agouti-related peptide-expressing neurons, which renders these cells less responsive to cues of low energy availability, significantly promotes CD4(+) T-cell activation by increasing production of T helper 1 and 17 proinflammatory...
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