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Article

Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins.

Scientific reports - 28 Sept 2015

Swaminathan Karthic, Stumpf Maria, Müller Rolf, Horn Anna-Carolin, Schmidbauer Julia, Eichinger Ludwig, Müller-Taubenberger Annette, Faix Jan, Noegel Angelika A

Abstract excerpt

Coronin7 (CRN7) stabilizes F-actin and is a regulator of processes associated with the actin cytoskeleton. Its loss leads to defects in phagocytosis, motility and development. It harbors a CRIB (Cdc42- and Rac-interactive binding) domain in each of its WD repeat domains which bind to Rac GTPases preferably in their GDP-loaded forms. Expression of wild type CRN7 in CRN7 deficient cells rescued these defects,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic AMP-Dependent Protein Kinases

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Source

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Identifiers

PMID: 26411260
DOI: 10.1038/srep14437
PMCID: PMC4585930

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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