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Article

The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusion.

EMBO reports - 1 Sept 2009

Gildor Boaz, Massarwa R'ada, Shilo Ben-Zion, Schejter Eyal D

Abstract excerpt

The actin nucleation-promoting factors SCAR/WAVE and WASp, together with associated elements, mediate the formation of muscle fibres through myoblast fusion during Drosophila embryogenesis. Our phenotypic analysis, following the disruption of these two pathways, suggests that they function in a sequential manner. Suppressor of cyclic AMP receptor (SCAR) activity is required before the formation of pores in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19644501
DOI: 10.1038/embor.2009.129
PMCID: PMC2750046

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The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusion.PMID 19644501Read ↗

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The WASP and WAVE family proteinsSemantic proximity Read ↗

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Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion.Semantic proximity Read ↗

WAVE Forms Hetero- and Homo-oligomeric Complexes at Integrin Junctions in Drosophila Visualized by Bimolecular Fluorescence ComplementationSemantic proximity Read ↗

CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis.Semantic proximity Read ↗

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complexSemantic proximity Read ↗

SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion.Semantic proximity Read ↗

Regulation of Actin Dynamics by WASP Family ProteinsSemantic proximity Read ↗

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