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Article

A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Swaminathan Karthic, Müller-Taubenberger Annette, Faix Jan, Rivero Francisco, Noegel Angelika A

Abstract excerpt

The Cdc42- and Rac-interactive binding motif (CRIB) of coronin binds to Rho GTPases with a preference for GDP-loaded Rac. Mutation of the Cdc42- and Rac-interactive binding motif abrogates Rac binding. This results in increased 1evels of activated Rac in coronin-deficient Dictyostelium cells (corA(-)), which impacts myosin II assembly. corA(-) cells show increased accumulation of myosin II in the cortex of...

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Identifiers

PMID: 24347642
DOI: 10.1073/pnas.1315368111
PMCID: PMC3890859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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