Article
Integrative genomics analysis of genes with biallelic loss and its relation to the expression of mRNA and micro-RNA in esophageal squamous cell carcinoma.
BMC genomics - 26 Sept 2015
Hu Nan, Wang Chaoyu, Clifford Robert J, Yang Howard H, Su Hua, Wang Lemin, Wang Yuan, Xu Yi, Tang Ze-Zhong, Ding Ti, Zhang Tongwu, Goldstein Alisa M, Giffen Carol, Lee Maxwell P, Taylor Philip R
Abstract excerpt
BACKGROUND: Genomic instability plays an important role in human cancers. We previously characterized genomic instability in esophageal squamous cell carcinomas (ESCC) in terms of loss of heterozygosity (LOH) and copy number (CN) changes in tumors. In the current study we focus on biallelic loss and its relation to expression of mRNA and miRNA in ESCC using results from 500 K SNP, mRNA, and miRNA arrays in 30...
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