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M2 Macrophage-Polarized Anti-inflammatory Microneedle Patch for Accelerating Biofilm-Infected Diabetic Wound Healing via Modulating the Insulin Pathway

2024-05-20

Abstract excerpt

<title>Abstract</title> <p>Macrophages play a pivotal role in the healing of diabetic ulcers. The sustained elevation of glucose levels damages the insulin signaling pathway in macrophages, leading to dysfunctional macrophages that struggle to transition from pro-inflammatory (M1) to reparative (M2) states. Therefore, modulating macrophage inflammatory responses via the insulin pathway holds promise for diabetic...

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Literature Corpus work: ce967f60-124f-5316-b79a-db4de6c52e26
DOI: 10.21203/rs.3.rs-4374698/v1

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