Article
CoVaMa: Co-Variation Mapper for disequilibrium analysis of mutant loci in viral populations using next-generation sequence data.
Methods (San Diego, Calif.) - 1 Dec 2015
Routh Andrew, Chang Max W, Okulicz Jason F, Johnson John E, Torbett Bruce E
Abstract excerpt
Next-Generation Sequencing (NGS) has transformed our understanding of the dynamics and diversity of virus populations for human pathogens and model systems alike. Due to the sensitivity and depth of coverage in NGS, it is possible to measure the frequency of mutations that may be present even at vanishingly low frequencies within the viral population. Here, we describe a simple bioinformatic pipeline called...
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