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Article

Correlated Allele Frequency Changes Reveal Clonal Structure and Selection in Temporal Genetic Data.

Molecular biology and evolution - 2 Apr 2024

Li Yunxiao, Barton John P

Abstract excerpt

In evolving populations where the rate of beneficial mutations is large, subpopulations of individuals with competing beneficial mutations can be maintained over long times. Evolution with this kind of clonal structure is commonly observed in a wide range of microbial and viral populations. However, it can be difficult to completely resolve clonal dynamics in data. This is due to limited read lengths in...

Topics

Humans
Escherichia coli
Gene Frequency
Mutation
Linkage Disequilibrium
Bacteria
Selection, Genetic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38507665
DOI: 10.1093/molbev/msae060
PMCID: PMC10986812

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