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Article

Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2016

Seipel Katja, Marques Miguel Teixera, Bozzini Marie-Ange, Meinken Christina, Mueller Beatrice U, Pabst Thomas

Abstract excerpt

PURPOSE: In acute myeloid leukemia (AML), the transcription factors CEBPA and KLF4 as well as the universal tumor suppressor p53 are frequently deregulated. Here, we investigated the extent of dysregulation, the molecular interactions, and the mechanisms involved. EXPERIMENTAL DESIGN: One hundred ten AML patient samples were analyzed for protein levels of CEBPA, KLF4, p53, and p53 modulators. Regulation of CEBPA...

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Topics

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Share to CCAAT-Enhancer-Binding Proteins
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Induction Chemotherapy

Share to Kruppel-Like Factor 4

Share to Kruppel-Like Transcription Factors

Share to Leukemia, Myeloid, Acute

Share to Transcriptional Activation

Source

Identifiers

PMID: 26408402
DOI: 10.1158/1078-0432.CCR-15-1054

Genes

KLF4
CUL9
MDM2
XPO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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