Article
p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status.
Leukemia - 1 Jun 2017
Quintás-Cardama A, Hu C, Qutub A, Qiu Y H, Zhang X, Post S M, Zhang N, Coombes K, Kornblau S M
Abstract excerpt
TP53 mutations are associated with the lowest survival rates in acute myeloid leukemia (AML). In addition to mutations, loss of p53 function can arise via aberrant expression of proteins that regulate p53 stability and function. We examined a large AML cohort using proteomics, mutational profiling and network analyses, and showed that (1) p53 stabilization is universal in mutant TP53 samples, it is frequent in...
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