ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia.

doi:10.1016/j.xcrm.2025.102540

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Article

ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia.

Cell reports. Medicine - 20 Jan 2026

Pereira-Martins Diego A, Ortiz Cesar, Weinhäuser Isabel, Wierenga Albertus T J, van den Boom Vincent, Mojallali Fatemeh, Sternadt Dominique, van der Meer Nisha K, Hogeling Shanna M, Bianco Thiago M, Chatzikyriakou Prodromos, Silveira Douglas R, Ammatuna Emanuele, Lucena-Araujo Antonio R, Quek Lynn, Huls Gerwin, Rego Eduardo M, Schuringa Jan Jacob

Abstract excerpt

Among acute myeloid leukemia (AML) patients, a subgroup remains notoriously refractory to current treatment options, with underlying mechanisms poorly understood. Here, using a multi-omics approach, we reveal that this resistant patient subgroup is characterized by high expression of the oncogenic TP73 isoform ΔNp73, exhibiting similarly poor outcomes as TP53-mutant AML. ΔNp73, which lacks a transcriptional...

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Identifiers

PMID: 41512877
DOI: 10.1016/j.xcrm.2025.102540
PMCID: PMC12866144

Genes

TP53
TP73

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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