Article
Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer.
Molecular cancer - 27 May 2014
Togashi Yosuke, Sakamoto Hiroki, Hayashi Hidetoshi, Terashima Masato, de Velasco Marco A, Fujita Yoshihiko, Kodera Yasuo, Sakai Kazuko, Tomida Shuta, Kitano Masayuki, Ito Akihiko, Kudo Masatoshi, Nishio Kazuto
Abstract excerpt
BACKGROUND: Transforming growth factor, beta (TGFB) signal is considered to be a tumor suppressive pathway based on the frequent genomic deletion of the SMAD4 gene in pancreatic cancer (PC); however; the role of the activin signal, which also belongs to the TGFB superfamily, remains largely unclear. METHODS AND RESULTS: We found a homozygous deletion of the activin A receptor, type IB (ACVR1B) gene in 2 out of 8...
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