Article
Whole-genome analysis of genetic recombination of hepatitis delta virus: molecular domain in delta antigen determining trans-activating efficiency.
The Journal of general virology - 1 Dec 2015
Chao Mei, Lin Chia-Chi, Lin Feng-Ming, Li Hsin-Pai, Iang Shan-Bei
Abstract excerpt
Hepatitis delta virus (HDV) is the only animal RNA virus that has an unbranched rod-like genome with ribozyme activity and is replicated by host RNA polymerase. HDV RNA recombination was previously demonstrated in patients and in cultured cells by analysis of a region corresponding to the C terminus of the delta antigen (HDAg), the only viral-encoded protein. Here, a whole-genome recombination map of HDV was...
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