Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.

doi:10.1371/journal.pgen.1005530

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Article

Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.

PLoS genetics - 1 Jan 2015

Roudnitzky Natacha, Behrens Maik, Engel Anika, Kohl Susann, Thalmann Sophie, Hübner Sandra, Lossow Kristina, Wooding Stephen P, Meyerhof Wolfgang

Abstract excerpt

The ability to taste bitterness evolved to safeguard most animals, including humans, against potentially toxic substances, thereby leading to food rejection. Nonetheless, bitter perception is subject to individual variations due to the presence of genetic functional polymorphisms in bitter taste receptor (TAS2R) genes, such as the long-known association between genetic polymorphisms in TAS2R38 and bitter taste...

Topics

Alleles
Animals
Genetic Association Studies
Genotype
Haplotypes
Humans
Iridoids
Phenylthiourea
Polymorphism, Single Nucleotide
Quassins
Quinine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, G-Protein-Coupled

Sesquiterpenes

Sesquiterpenes, Guaiane

Taste Buds

Taste Perception

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 26406243
DOI: 10.1371/journal.pgen.1005530
PMCID: PMC4583475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26406243-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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