Article
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
The Journal of clinical investigation - 1 Mar 2018
Guo Liang, Akahori Hirokuni, Harari Emanuel, Smith Samantha L, Polavarapu Rohini, Karmali Vinit, Otsuka Fumiyuki, Gannon Rachel L, Braumann Ryan E, Dickinson Megan H, Gupta Anuj, Jenkins Audrey L, Lipinski Michael J, Kim Johoon, Chhour Peter, de Vries Paul S, Jinnouchi Hiroyuki, Kutys Robert, Mori Hiroyoshi, Kutyna Matthew D, Torii Sho, Sakamoto Atsushi, Choi Cheol Ung, Cheng Qi, Grove Megan L, Sawan Mariem A, Zhang Yin, Cao Yihai, Kolodgie Frank D, Cormode David P, Arking Dan E, Boerwinkle Eric, Morrison Alanna C, Erdmann Jeanette, Sotoodehnia Nona, Virmani Renu, Finn Aloke V
Abstract excerpt
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non-foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and a mouse model of advanced atherosclerosis, we investigated...
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