Molecular mechanisms underlying variations in lung function: a systems genetics analysis.

doi:10.1016/S2213-2600(15)00380-X

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Article

Molecular mechanisms underlying variations in lung function: a systems genetics analysis.

The Lancet. Respiratory medicine - 1 Oct 2015

Obeidat Ma'en, Hao Ke, Bossé Yohan, Nickle David C, Nie Yunlong, Postma Dirkje S, Laviolette Michel, Sandford Andrew J, Daley Denise D, Hogg James C, Elliott W Mark, Fishbane Nick, Timens Wim, Hysi Pirro G, Kaprio Jaakko, Wilson James F, Hui Jennie, Rawal Rajesh, Schulz Holger, Stubbe Beate, Hayward Caroline, Polasek Ozren, Järvelin Marjo-Riitta, Zhao Jing Hua, Jarvis Deborah, Kähönen Mika, Franceschini Nora, North Kari E, Loth Daan W, Brusselle Guy G, Smith Albert Vernon, Gudnason Vilmundur, Bartz Traci M, Wilk Jemma B, O'Connor George T, Cassano Patricia A, Tang Wenbo, Wain Louise V, Soler Artigas María, Gharib Sina A, Strachan David P, Sin Don D, Tobin Martin D, London Stephanie J, Hall Ian P, Paré Peter D

Abstract excerpt

BACKGROUND: Lung function measures reflect the physiological state of the lung, and are essential to the diagnosis of chronic obstructive pulmonary disease (COPD). The SpiroMeta-CHARGE consortium undertook the largest genome-wide association study (GWAS) so far (n=48,201) for forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) in the general population. The lung...

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PMID: 26404118
DOI: 10.1016/S2213-2600(15)00380-X
PMCID: PMC5021067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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