Lung eQTLs to help reveal the molecular underpinnings of asthma.

doi:10.1371/journal.pgen.1003029

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Article

Lung eQTLs to help reveal the molecular underpinnings of asthma.

PLoS genetics - 1 Jan 2012

Hao Ke, Bossé Yohan, Nickle David C, Paré Peter D, Postma Dirkje S, Laviolette Michel, Sandford Andrew, Hackett Tillie L, Daley Denise, Hogg James C, Elliott W Mark, Couture Christian, Lamontagne Maxime, Brandsma Corry-Anke, van den Berge Maarten, Koppelman Gerard, Reicin Alise S, Nicholson Donald W, Malkov Vladislav, Derry Jonathan M, Suver Christine, Tsou Jeffrey A, Kulkarni Amit, Zhang Chunsheng, Vessey Rupert, Opiteck Greg J, Curtis Sean P, Timens Wim, Sin Don D

Abstract excerpt

Genome-wide association studies (GWAS) have identified loci reproducibly associated with pulmonary diseases; however, the molecular mechanism underlying these associations are largely unknown. The objectives of this study were to discover genetic variants affecting gene expression in human lung tissue, to refine susceptibility loci for asthma identified in GWAS studies, and to use the genetics of gene expression...

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PMID: 23209423
DOI: 10.1371/journal.pgen.1003029
PMCID: PMC3510026

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GSDMA
SOCS3

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