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Article

The obesity paradox in cognitive decline: Impact of BMI dynamics and APOE genotypes across various cognitive status.

Diabetes, obesity & metabolism - 1 Jul 2025

Zhai Weijie, Zhang Guimei, Wei Chunxiao, Zhao Meng, Sun Li

Abstract excerpt

AIMS: To explore the relationship between body mass index (BMI) and its changes in relation to cognitive decline across different cognitive status, while also examining the role of the APOE genotype in these associations. MATERIALS AND METHODS: A total of 23 255 individuals from the National Alzheimer's Coordinating Center (NACC) were analysed using multivariable logistic and Cox regression to assess BMI and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40317984
DOI: 10.1111/dom.16433
PMCID: PMC12146477

Genes

APOE

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