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Article

Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease.

Journal of molecular neuroscience : MN - 1 Jan 2005

Wang Binbin, Jin Feng, Kan Rui, Ji Shun, Zhang Chuanfang, Lu Zeping, Zheng Chenguang, Yang Ze, Wang Li

Abstract excerpt

Increased total plasma homocysteine (t-Hcy) levels are found to be associated with Alzheimer's disease (AD). Because the methylenetetrahydrofolate reductase (MTHFR) gene encodes a key enzyme that influences the metabolism of homocysteine, it has been considered as a possible genetic risk factor for AD. Although the MTHFR gene C677T polymorphism has a significant impact on reducing enzyme activity and increasing...

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Source

Identifiers

PMID: 16055944
DOI: 10.1385/JMN:27:1:023

Genes

MTHFR
APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease.PMID 16055944Read ↗

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