Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease.

doi:10.1385/JMN:27:1:023

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Article

Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease.

Journal of molecular neuroscience : MN - 1 Jan 2005

Wang Binbin, Jin Feng, Kan Rui, Ji Shun, Zhang Chuanfang, Lu Zeping, Zheng Chenguang, Yang Ze, Wang Li

Abstract excerpt

Increased total plasma homocysteine (t-Hcy) levels are found to be associated with Alzheimer's disease (AD). Because the methylenetetrahydrofolate reductase (MTHFR) gene encodes a key enzyme that influences the metabolism of homocysteine, it has been considered as a possible genetic risk factor for AD. Although the MTHFR gene C677T polymorphism has a significant impact on reducing enzyme activity and increasing...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 16055944
DOI: 10.1385/JMN:27:1:023

Genes

MTHFR
APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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