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Article

A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease.

Neurobiology of aging - 1 Mar 2004

Wakutani Yosuke, Kowa Hisanori, Kusumi Masayoshi, Nakaso Kazuhiro, Yasui Ken-Ichi, Isoe-Wada Kenji, Yano Hidetaka, Urakami Katsuya, Takeshima Takao, Nakashima Kenji

Abstract excerpt

Epidemiological studies have shown that elevated plasma homocysteine (Hcy) levels play an important role in the pathogenesis of Alzheimer's disease (AD). In spite of the evidence that a C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene elevates plasma Hcy levels, the impact of the C677T polymorphism on the development of AD is controversial. Here, we performed a genetic case-control study...

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PMID: 15123333
DOI: 10.1016/S0197-4580(03)00082-4

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease.PMID 15123333Read ↗

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