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SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4

8 Jan 2021

Abstract excerpt

Several studies have analyzed antiviral immune pathways in late-stage severe COVID-19. However, the initial steps of SARS-CoV-2 antiviral immunity are poorly understood. Here we have isolated primary SARS-CoV-2 viral strains and studied their interaction with human plasmacytoid predendritic cells (pDCs), a key player in antiviral immunity. We show that pDCs are not productively infected by SARS-CoV-2. However,...

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PMID: 33533916
DOI: 10.1084/jem.20201387

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