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Article

A non-signaling role of Robo2 in tendons is essential for Slit processing and muscle patterning.

Development (Cambridge, England) - 15 Oct 2015

Ordan Elly, Volk Talila

Abstract excerpt

Coordinated locomotion of an organism relies on the development of proper musculoskeletal connections. In Drosophila, the Slit-Robo signaling pathway guides muscles to tendons. Here, we show that the Slit receptor Roundabout 2 (Robo2) plays a non-cell-autonomous role in directing muscles to their corresponding tendons. Robo2 is expressed by tendons, and its non-signaling activity in these cells promotes Slit...

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Identifiers

PMID: 26400093
DOI: 10.1242/dev.128157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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