Article
Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions.
eLife - 18 Jun 2014
Subramanian Arul, Schilling Thomas F
Abstract excerpt
Tendons are extracellular matrix (ECM)-rich structures that mediate muscle attachments with the skeleton, but surprisingly little is known about molecular mechanisms of attachment. Individual myofibers and tenocytes in Drosophila interact through integrin (Itg) ligands such as Thrombospondin (Tsp), while vertebrate muscles attach to complex ECM fibrils embedded with tenocytes. We show for the first time that a...
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