In chordoma, metastasis, recurrences, Ki-67 index, and a matrix-poor phenotype are associated with patients' shorter overall survival.

doi:10.1007/s00586-015-4242-1

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Article

In chordoma, metastasis, recurrences, Ki-67 index, and a matrix-poor phenotype are associated with patients' shorter overall survival.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Dec 2016

von Witzleben Adrian, Goerttler Lukas T, Lennerz Jochen, Weissinger Stephanie, Kornmann Marko, Mayer-Steinacker Regine, von Baer Alexandra, Schultheiss Markus, Möller Peter, Barth Thomas F E

Abstract excerpt

PURPOSE: To establish a chordoma tissue cohort (n = 43) and to correlate localization, size, metastasis, residual disease (R-status), recurrences, histological subtype, matrix content, and Ki-67 proliferation index with patients' overall survival (OS). METHODS AND RESULTS: We used routine histopathology supplemented by immunohistochemistry. In our patient cohort (median age 69 years, range 17 to 84 years) the...

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PMID: 26399506
DOI: 10.1007/s00586-015-4242-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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