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Article

M2-polarized macrophages contribute to the decreased sensitivity of EGFR-TKIs treatment in patients with advanced lung adenocarcinoma.

Medical oncology (Northwood, London, England) - 1 Aug 2014

Zhang Bicheng, Zhang Yafei, Zhao Jie, Wang Zhigang, Wu Tingting, Ou Wuling, Wang Jun, Yang Bo, Zhao Yong, Rao Zhiguo, Gao Jianfei

Abstract excerpt

Previous study has revealed that tumor-associated macrophages (TAMs) correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC). In the present study, we further determined that M2-TAMs, but not M1-TAMs, are related to the treatment response to EGFR-TKIs in advanced NSCLC and may be an independent predictor of survival....

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Source

Identifiers

PMID: 25034365
DOI: 10.1007/s12032-014-0127-0

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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