Article
Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Dec 2016
Meis Jacques F, Chowdhary Anuradha, Rhodes Johanna L, Fisher Matthew C, Verweij Paul E
Abstract excerpt
Aspergillus fungi are the cause of an array of diseases affecting humans, animals and plants. The triazole antifungal agents itraconazole, voriconazole, isavuconazole and posaconazole are treatment options against diseases caused by Aspergillus However, resistance to azoles has recently emerged as a new therapeutic challenge in six continents. Although de novo azole resistance occurs occasionally in patients...
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