Article
BMAL1-dependent regulation of the mTOR signaling pathway delays aging.
Aging - 1 Jan 2014
Khapre Rohini V, Kondratova Anna A, Patel Sonal, Dubrovsky Yuliya, Wrobel Michelle, Antoch Marina P, Kondratov Roman V
Abstract excerpt
The circadian clock, an internal time-keeping system, has been linked with control of aging, but molecular mechanisms of regulation are not known. BMAL1 is a transcriptional factor and core component of the circadian clock; BMAL1 deficiency is associated with premature aging and reduced lifespan. Here we report that activity of mammalian Target of Rapamycin Complex 1 (mTORC1) is increased upon BMAL1 deficiency...
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