Article
The population genetics and dynamics of the thalassemias.
Hematology/oncology clinics of North America - 1 Dec 2010
Weatherall D J, Williams T N, Allen S J, O'Donnell A
Abstract excerpt
The inherited disorders of hemoglobin, including the thalassemias, are by far the commonest monogenic diseases. Although several factors are responsible for their very high frequency, the major mechanism seems to be natural selection mediated by heterozygote protection against severe forms of malaria. Recent work has highlighted the complexity of the interplay among the different hemoglobin variants themselves...
Topics
- Genetic Heterogeneity
- Genetic Variation
- Genetics, Population
- Hemoglobinopathies
- Hemoglobins
- Heterozygote
- Humans
- Malaria
- Selection, Genetic
- Thalassemia