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Article

Evolutionary history of sickle-cell mutation: implications for global genetic medicine.

Human molecular genetics - 26 Apr 2021

Esoh Kevin, Wonkam Ambroise

Abstract excerpt

Resistance afforded by the sickle-cell trait against severe malaria has led to high frequencies of the sickle-cell mutation [HBB; c.20T>A, p.Glu6Val; OMIM: 141900 (HBB-βS)] in most parts of Africa. High-coverage sequencing and genotype data have now confirmed the single African origin of the sickle-cell gene variant [HBB; c.20T>A, p.Glu6Val; OMIM: 141900 (HBB-βS)]. Nevertheless, the classical HBB-like genes...

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Identifiers

PMID: 33461216
DOI: 10.1093/hmg/ddab004
PMCID: PMC8117455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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