Article
The population genetics of the haemoglobinopathies.
Bailliere's clinical haematology - 1 Mar 1998
Flint J, Harding R M, Boyce A J, Clegg J B
Abstract excerpt
The haemoglobinopathies are the commonest single-gene disorders known, almost certainly because of the protection they provide against malaria, as attested by a number of observations. The geographical distributions of malaria and haemoglobinopathies largely overlap, and microepidemiological surveys confirm the close relationship between them. For two of the commonest disorders, haemoglobin S and...
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