Loss of balancing selection in the betaS globin locus.

doi:10.1186/1471-2350-11-21

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Article

Loss of balancing selection in the betaS globin locus.

BMC medical genetics - 3 Feb 2010

Salih Niven A, Hussain Ayman A, Almugtaba Ibrahim A, Elzein Abeir M, Elhassan Ibrahim M, Khalil Eltahir A G, Ishag Hani B, Mohammed Hiba S, Kwiatkowski Dominic, Ibrahim Muntaser E

Abstract excerpt

BACKGROUND: Probably the best example of the rise and maintenance of balancing selection as an evolutionary trend is the role of S-haemoglobin (HbS - rs334) in protecting from malaria. Yet, the dynamics of such a process remains poorly understood, particularly in relation to different malaria transmission rates and the genetic background of the affected populations. METHODS: We investigated the association of...

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PMID: 20128890
DOI: 10.1186/1471-2350-11-21
PMCID: PMC2829010

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