Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme.

Journal of neurochemistry - 1 Oct 2016

Adolf Andrej, Leondaritis George, Rohrbeck Astrid, Eickholt Britta Johanna, Just Ingo, Ahnert-Hilger Gudrun, Höltje Markus

Abstract excerpt

The type III intermediate filament protein vimentin was recently identified to mediate binding and uptake of Clostridium botulinum C3 exoenzyme (C3bot) in two cell lines. Here, we used primary neuronal cultures from vimentin knockout (Vim-/- ) mice to study the impact of vimentin on axonal growth and internalization of C3bot. In contrast to wild type, vimentin knockout neurons were insensitive to C3bot....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate Ribose
Share to ADP Ribose Transferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Botulinum Toxins

Share to Mice, 129 Strain

Share to Primary Cell Culture

Share to rho GTP-Binding Proteins

Share to rhoA GTP-Binding Protein

Share to Vimentin

Source

Identifiers

PMID: 27419376
DOI: 10.1111/jnc.13739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme.PMID 27419376Read ↗

Vimentin on the move: new developments in cell migrationSemantic proximity Read ↗

Plasticin, a type III neuronal intermediate filament protein, assembles as an obligate heteropolymer: implications for axonal flexibility.Semantic proximity Read ↗

Ultrastructural studies of carboxyl-terminal truncation mutants of the neuronal intermediate filament protein peripherin.Semantic proximity Read ↗

C3 exoenzyme lacks effects on peripheral axon regeneration in vivo.Semantic proximity Read ↗

Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme.Semantic proximity Read ↗

Vimentin Intermediate Filaments Maintain Membrane Potential of Mitochondria in Growing NeuritesSemantic proximity Read ↗

Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis.Semantic proximity Read ↗

Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease.Semantic proximity Read ↗

Abnormal intermediate filament organization alters mitochondrial motility in giant axonal neuropathy fibroblasts.Semantic proximity Read ↗

Impaired neurotrophin-3 signaling in a TrkAII mutant associated with hereditary polyneuropathy.Semantic proximity Read ↗

Cell Surface Vimentin Is an Attachment Receptor for Enterovirus 71Semantic proximity Read ↗

Inhibition of CRMP2 phosphorylation repairs CNS by regulating neurotrophic and inhibitory responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.