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Article

Time-resolved cellular effects induced by TcdA from Clostridium difficile.

Rapid communications in mass spectrometry : RCM - 30 May 2014

Jochim Nelli, Gerhard Ralf, Just Ingo, Pich Andreas

Abstract excerpt

RATIONALE: The anaerobe Clostridium difficile is a common pathogen that causes infection of the colon leading to diarrhea or pseudomembranous colitis. Its major virulence factors are toxin A (TcdA) and toxin B (TcdB), which specifically inactivate small GTPases by glucosylation leading to reorganization of the cytoskeleton and finally to cell death. In the present work a quantitative proteome analysis using the...

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PMID: 24711272
DOI: 10.1002/rcm.6882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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