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Article

Subjecting appropriate lung adenocarcinoma samples to next-generation sequencing-based molecular testing: challenges and possible solutions.

Molecular oncology - 1 May 2018

Li Weihua, Qiu Tian, Ling Yun, Gao Shugeng, Ying Jianming

Abstract excerpt

Next-generation sequencing (NGS) has recently been rapidly adopted in the molecular diagnosis of cancer, but it still faces some obstacles. In this study, 665 lung adenocarcinoma samples (558 TKI-naive and 107 TKI-relapsed samples) were interrogated using NGS, and the challenges and possible solutions of subjecting appropriate tissue samples to NGS testing were explored. The results showed that lower frequencies...

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Identifiers

PMID: 29518290
DOI: 10.1002/1878-0261.12190
PMCID: PMC5928389

Genes

EGFR
KRAS
BRAF
MAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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