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Article

Intratumoral Heterogeneity of ALK-Rearranged and ALK/EGFR Coaltered Lung Adenocarcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Nov 2015

Cai Weijing, Lin Dongmei, Wu Chunyan, Li Xuefei, Zhao Chao, Zheng Limou, Chuai Shannon, Fei Ke, Zhou Caicun, Hirsch Fred R

Abstract excerpt

PURPOSE: Genetic intratumoral heterogeneity has a profound influence on the selection of clinical treatment strategies and on addressing resistance to targeted therapy. The purpose of this study was to explore the potential effect of intratumoral heterogeneity on both genetic and pathologic characteristics of ALK-rearranged lung adenocarcinoma (LADC). METHODS: We tested ALK fusions and EGFR mutations in 629...

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Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anaplastic Lymphoma Kinase

Share to Gene Rearrangement

Share to In Situ Hybridization, Fluorescence

Share to Laser Capture Microdissection

Share to Oncogene Proteins, Fusion

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 26416997
DOI: 10.1200/JCO.2014.58.8293
PMCID: PMC4770798

Genes

ALK
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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