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Article

Consistent mutation status within histologically heterogeneous lung cancer lesions.

Histopathology - 1 Oct 2012

Mattsson Johanna Sofia Margareta, Imgenberg-Kreuz Juliana, Edlund Karolina, Botling Johan, Micke Patrick

Abstract excerpt

AIMS: Activating epidermal growth factor receptor (EGFR) and KRAS mutations characterize molecular subgroups of non-small-cell lung cancer (NSCLC) with a strong predictive value for response to EGFR inhibitor therapy. However, the temporal occurrence and clonal stability of these mutations during...

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Source

Identifiers

PMID: 22458769
DOI: 10.1111/j.1365-2559.2012.04245.x

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22458769-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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