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Article

Consistent mutation status within histologically heterogeneous lung cancer lesions.

Histopathology - 1 Oct 2012

Mattsson Johanna Sofia Margareta, Imgenberg-Kreuz Juliana, Edlund Karolina, Botling Johan, Micke Patrick

Abstract excerpt

AIMS: Activating epidermal growth factor receptor (EGFR) and KRAS mutations characterize molecular subgroups of non-small-cell lung cancer (NSCLC) with a strong predictive value for response to EGFR inhibitor therapy. However, the temporal occurrence and clonal stability of these mutations during the course of cancer progression are debated. The aim of this study was to characterize the presence of EGFR and KRAS...

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Identifiers

PMID: 22458769
DOI: 10.1111/j.1365-2559.2012.04245.x

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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