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Article

Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer.

Blood - 14 Jun 2012

Yao Xin, Ahmadzadeh Mojgan, Lu Yong-Chen, Liewehr David J, Dudley Mark E, Liu Fang, Schrump David S, Steinberg Seth M, Rosenberg Steven A, Robbins Paul F

Abstract excerpt

CD4(+)FoxP3(+) regulatory T cells (Tregs) have been shown to suppress T cell-mediated host immune responses against self- and nonself-antigens; however, the impact of CD4(+) Tregs on human antitumor immune responses and their influence on cancer treatment are unknown. In the present study, we explored the factors that influence CD4(+) Treg reconstitution in patients receiving adoptive immunotherapy following...

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Share to CD4 Antigens
Share to Dose-Response Relationship, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy, Adoptive

Share to Interleukin-2

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Share to Lymphocytes, Tumor-Infiltrating

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Source

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Identifiers

PMID: 22555974
DOI: 10.1182/blood-2011-10-386482
PMCID: PMC3382928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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