Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

18 Sept 2015

Abstract excerpt

Cellular senescence has been associated with the structural and functional decline observed during physiological lung aging and in chronic obstructive pulmonary disease (COPD). Airway epithelial cells are the first line of defense in the lungs and are important to COPD pathogenesis. However, the mechanisms underlying airway epithelial cell senescence, and particularly the role of telomere dysfunction in this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Telomeres, Telomerase, and Senescence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26386121
DOI: 10.1152/ajplung.00293.2015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary diseasePMID 26386121Read ↗

Lung cellular senescence is independent of aging in a mouse model of COPD/emphysemaSemantic proximity Read ↗

Telomere length is a determinant of emphysema susceptibility.Semantic proximity Read ↗

Telomere Shortening and Its Association with Cell Dysfunction in Lung DiseasesSemantic proximity Read ↗

Telomeres in lung disease.Semantic proximity Read ↗

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary DiseaseSemantic proximity Read ↗

Telomere-mediated lung diseaseSemantic proximity Read ↗

Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axisSemantic proximity Read ↗

Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axisSemantic proximity Read ↗

Smoking accelerates aging of the small airway epitheliumSemantic proximity Read ↗

DNA damage due to oxidative stress in Chronic Obstructive Pulmonary Disease (COPD).Semantic proximity Read ↗

Cellular senescence in chronic obstructive pulmonary disease: Molecular mechanisms and therapeutic interventionsSemantic proximity Read ↗

Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.