Article
Telomere length is a determinant of emphysema susceptibility.
American journal of respiratory and critical care medicine - 15 Oct 2011
Alder Jonathan K, Guo Nini, Kembou Frant, Parry Erin M, Anderson Collin J, Gorgy Amany I, Walsh Michael F, Sussan Thomas, Biswal Shyam, Mitzner Wayne, Tuder Rubin M, Armanios Mary
Abstract excerpt
RATIONALE: Germline mutations in the enzyme telomerase cause telomere shortening, and have their most common clinical manifestation in age-related lung disease that manifests as idiopathic pulmonary fibrosis. Short telomeres are also a unique heritable trait that is acquired with age. OBJECTIVES: We sought to understand the mechanisms by which telomerase deficiency contributes to lung disease. METHODS: We studied...
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