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Article

Structural Insights into mitochondrial antiviral signaling protein (MAVS)-tumor necrosis factor receptor-associated factor 6 (TRAF6) signaling.

The Journal of biological chemistry - 30 Oct 2015

Shi Zhubing, Zhang Zhen, Zhang Zhenzhen, Wang Yanyan, Li Chuanchuan, Wang Xin, He Feng, Sun Lina, Jiao Shi, Shi Weiyang, Zhou Zhaocai

Abstract excerpt

In response to viral infection, cytosolic retinoic acid-inducible gene I-like receptors sense viral RNA and promote oligomerization of mitochondrial antiviral signaling protein (MAVS), which then recruits tumor necrosis factor receptor-associated factor (TRAF) family proteins, including TRAF6, to activate an antiviral response. Currently, the interaction between MAVS and TRAF6 is only partially understood, and...

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Identifiers

PMID: 26385923
DOI: 10.1074/jbc.M115.666578
PMCID: PMC4646334

Genes

MAVS
TRAF6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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