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Article

Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling

25 Jun 2018

Abstract excerpt

Flaviviruses have evolved complex mechanisms to evade the mammalian host immune systems including the RIG-I (retinoic acid-inducible gene I) like receptor (RLR) signaling. Zika virus (ZIKV) is a re-emerging flavivirus that is associated with severe neonatal microcephaly and adult Guillain-Barre syndrome. However, the molecular mechanisms underlying ZIKV pathogenesis remain poorly defined. Here we report that ZIKV...

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PMID: 29988497
DOI: 10.3389/fmicb.2018.01350

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